EpiGuide

Epi-Guide® is fabricated from polylactic acid and is the only bio-resorbable synthetic membrane with a unique 3-layer technology to provide predictable healing while maintaining sufficient rigidity.

Epi-Guide is indicated for use as an adjunct to periodontal restorative surgeries in the treatment of periodontal defects following established surgical procedures.

High-tech Architecture — Maintains Space / Helps Arrest Epithelial Migration
Synthetic Construction — Avoid Risks of Disease from Biological Products
Completely Resorbable — Second Surgery Unnecessary to Remove Membranes

Visible Healing in Your Patients

View Cerasorb in Action
How EpiGuide Works
  1. Forms a natural barrier to promote soft-tissue healing.
  2. Maintains architecture and structural integrity for up to 20 weeks after implantation.
  3. Complete bioresorption occurs between 6 and 12 months.
  4. Regenerates tissue despite flap recession or if primary closure is not obtained.

The Epi-Guide Bioresorbable Barrier Matrix is a membrane designed for use as an adjunct to periodontal restorative surgeries and assists in the regeneration of bone and periodontal support tissues. It is a porous, three-dimensional matrix fabricated from D, D-L, L polylactic acid, a bioresorbable polymer with a long history of safe medical use. The barrier’s three-layer construction is deigned to attract, trap, and retain fibroblasts and epithelial cells while maintaining space around teeth for development of bone and periodontal support tissues. The Epi-Guide maintains its architecture and structural integrity for 20 weeks after implantation with complete bioresorption between 6-12 months.

The Epi-Guide Barrier is a hydrophilic membrane that quickly absorbs blood fluid and clinical investigations have revealed that, once implanted in the body, Epi-Guide functions to support the initial blood clot and maintain competence of collateral circulation. Should the barrier become exposed or if primary closure is not obtained, clotted blood within the barrier provides a natural matrix which allows tissue to quickly grow and cover most exposures. The Epi-Guide Barrier is self-supporting and can be used in many situations without support from bone grafting materials.


EpiGuide

Actual Size is 18X30 mm

Layer 3: Gingival Interface
Numerous voids and intercommunicating pathways enhance fibroblast infiltration and cell attachment.

Layer 2: Inner Surface
Inner labyrinth creates pathways, while internal chambers enable collateral circulation and flow of interstitial fluid in the membrane.

Layer 1: Defect Interface
Limited porosity supports an uptake of fluid, helps adherence to the tooth surface, and inhibits fibroblast movement.


EpiGuide - 6 Weeks
Six Weeks
Numerous fronds of connective tissue penetrate the Epi-Guide Barrier and new collagen fibers begin to form within the matrix, with no evidence of acute inflammatory response.

EpiGuide - 13 Weeks
Thirteen Weeks
Fronds of connective tissue continue to penetrate the Epi-Guide Barrier and display collagen fiber formation. The barrier remains functional despite initiation of the resorption process. Surrounding connective tissue is normal in appearance.


EpiGuide Placement Guide

Place the Epi-Guide, smooth side towards the defect. Ensure the membrane covers the entire defect.

Epi-Guide preserves the space around the teeth for development of bone and periodontal support tissues. It maintains architecture and structural integrity for 20 weeks after implantation with complete bioresorption occuring in 6 to 12 months.

Epi-Guide comes in a sterilized 18 × 30 mm single mebrane sheet ready for easy specialized shaping. The sterile sheet resides in an outer package protected for shipping.

Product Code Product name
50600-02 Epi-Guide 18mm x 30mm

Maufactured by Kensey Nash Corp.


Pictures

  • Postoperative view of first molar class II furcation defect prior to placement of an Epi-Guide barrier.
  • 12 month postoperative reentry reveals adequate bone healing.

EpiGuide FAQ

What are the ingredients in EpiGuide?

EpiGuide is made of polylactic acid (PLA) which helps it maintains its structure with consistent resorption.

For which indications can I use EpiGuide?

EpiGuide can be used for GBR and GTR indications.

How do I prepare and fit EpiGuide into the surgical area?

EpiGuide comes in a sterilized 18 ×30 mm single dental membrane sheet which maintains sufficient rigidity and malleability after removal from its sterile packaging so it can be easily cut and shaped. After it is placed in the surgical site, the surrounding tissues will moisten the membrane, allowing for excellent resorption.

How long will EpiGuide maintain its integrity?

It will maintain its architecture and structural integrity for up to 20 weeks after implantation. Complete resorption will occur between 6 and 12 months, depending on the location and the patient’s health.


Additional Resources

Hermann, 2007: Clinical Observations on the New Epi-Guide® Barrier Matrix in Periodontological and Implantological Indications


Vernino et al, 1995: Ridge Preservation of Dentition With Severe Periodontitis


Vernino et al, 1998: Use of Biodegradable Polylactic Acid Barrier Materials in the Treatment of Grade II Periodontal Furcation Defects in Humans, Part I


Vernino et al, 1998: Use of Biodegradable Polylactic Acid Barrier Materials in the Treatment of Grade II Periodontal Furcation Defects in Humans, Part II


Yang, Lee, Vernino, 2000: Ridge Preservation of Dentition With Severe Periodontitis